Theilovirus seqs

Virus	Strain	Region	Length	Accession No.	Reference	Comments
Theiler's murine encephalomyelitis virus (TMEV)
TMEV	GD VII (New York/37)	3C+3D+3' NCR	1924	M14703	Ozden et al., 1986
		CG	8105	M20562	Pevear et al., 1988
		CG	8101	X56019	Law et al., 1990
TMEV	DA (Boston/52)	CG	8093	M20301	Ohara et al., 1988
TMEV	BeAn 8386 (Brazil/57)	CG	8098	M16020	Pevear et al., 1987
TMEV	M2 (from BeAn 8386)	L+P1	2766	AF030574	Kim et al., 1998	low-pathogenic M2 variant of strain BeAn 8386
TMEV	S2 (variant of BeAn 8386)	CG	8100	DQ401688	Myoung et al., 2007
TMEV	TO4 (New York/37)	5'NCR(p)	534	M80885	Pritchard et al., 1992b
TMEV	TO4 (New York/37)	L+P1	2760	U33045	Michiels et al., 1995
TMEV	TO4 (B15)	5'NCR(p)	521	M80886	Pritchard et al., 1992b
TMEV	FA (New York/37)	5'NCR(p)	532	M80883	Pritchard et al., 1992b
TMEV	FA (New York/37)	L+P1	2766	U32924	Michiels et al., 1995
TMEV	TO Yale (1943)	5'NCR(p)	529	M80890	Pritchard et al., 1992b
TMEV	TO Yale (1943)	L+P1	2766	U33047	Michiels et al., 1995
TMEV	WW (Philadelphia/77)	5'NCR(p)	534	M80889	Pritchard et al., 1992b
TMEV	WW (Philadelphia/77)	L+P1	2760	U33046	Michiels et al., 1995
TMEV	VL	5'NCR+L(p)	1100	M80887	Pritchard et al., 1992b
TMEV	ASK-1	P1	2649	U20288	Luo et al., unpublished
TMEV	?	5'UTR(p)	58	S61105	Bandyopadhyay et al., 1993
TMEV	MHG*	5'NCR(p)+L(p)	521	M80884	Pritchard et al., 1992b
Vilyuisk human encephalomyelitis virus (VHEV)
VHEV	V1/Siberia/55	5' NCR(p)	966	M80888	Pritchard et al., 1992b
VHEV	V1/Siberia/55	L+P1	2790	M94868	Pritchard et al., 1992a
Thera virus (TRV) [formerly known as Theiler-like virus (TLV) of rats]
TRV	NGS910	CG	8021	AB090161	Ohsawa et al., 2003	5' end missing (~73 nt)
Saffold virus 1 (SAFV-1)
SAFV-1	California/81	CG	8115	EF165067	Jones et al., 2007
Saffold virus 2 (SAFV-2)
SAFV-2	Can112051-06	pp-coding region	6882	AM922293	Abed and Boivin, 2008
SAFV-2	no name specified	CG	7961	EU376394	Chiu & DeRisi, unpublished	approx. 90 nt missing from 5' end
* also known as rat encephalomyelitis virus CG = complete genome; (p) = partial gene sequence

References

Abed, Y. and Boivin, G. (2008). New Saffold cardioviruses in 3 children, Canada. Emerging Infectious Diseases 14: 834-836.

Bandyopadhyay, P.K., Pritchard, A., Jensen, K. and Lipton, H.L. (1993). A three-nucleotide insertion in the H stem-loop of the 5' untranslated region of Theiler's virus attenuates neurovirulence. J. Virol. 67: 3691-3695.

Chiu, C.Y. and DeRisi, J.L. Identification of novel cardioviruses related to Theiler's murine encephalomyelitis viruses in human cases of gastroenteritis and influenza-like illness. Unpublished. [Biochemistry and Biophysics, University of California San Francisco, 1700 4th Street S404 Byers Hall DeRisi Lab, San Francisco, CA 91745, USA]

Jones, M.S., Lukashov, V.V., Ganac, R.D., Schnurr, D.P. (2007). Discovery of a novel human picornavirus from a pediatric patient presenting with fever of unknown origin. J. Clin. Microbiol. 45: 2144-2150.

Kim, B.S., Yauch, R.L., Bahk, Y.Y., Kang, J.A., Dal Canto, M.C. and Hall, C.K. (1998). A spontaneous low-pathogenic variant of Theiler's virus contains an amino acid substitution within the predominant VP1(233-250) T-cell epitope. J. Virol. 72: 1020-1027. Erratum in: J. Virol 1998 72: 6965.

Law, K.M. and Brown, T.D.K. (1990). The complete nucleotide sequence of the GDVII strain of Theiler's murine encephalomyelitis virus (TMEV). Nucl. Acids Res. 18: 6707-6708.

Luo, M., Pritchard, A.E. and Lipton, H. The Structure of a Highly Virulent Theiler's Murine Encephalomyelitis Virus (GDVII strain) and Implications for Determinants of Viral Persistence. Unpublished. (Pritchard A. E., University Colorado Health Sciences Center, Biochemistry, Biophysics and Genetics, 4200 E. Ninth, Denver, CO 80262, USA)

Michiels, T., Jarousse, N. and Brahic, M. (1995). Analysis of the leader and capsid coding regions of persistent and neurovirulent strains of Theiler's virus. Virology 214: 550-558.

Myoung, J., Hou, W., Kang, B., Lyman, M.A., Kang, J.-A. and Kim, B.S. (2007). The immunodominant CD8+ T cell epitope region of Theiler's virus in resistant C57BL/6 mice is critical for anti-viral immune responses, viral persistence, and binding to the host cells. Virology 360: 159-171.

Ohara, Y., Stein, S., Fu, J., Stillman, L., Klaman, L. and Roos, R.P. (1988). Molecular cloning and sequence determination of DA strain of Theiler's murine encephalomyelitis viruses. Virology 164: 245-255.

Ohsawa, K., Watanabe, Y., Miyata, H., Sato, H. (2003). Genetic analysis of a Theiler-like virus isolated from rats. Comp Med. 53: 191-196.

Ozden, S., Tangy, F., Chamorro, M. and Brahic, M. (1986). Theiler's virus genome is closely related to that of encephalomyocarditis virus, the prototype cardiovirus. J. Virol. 60: 1163-1165.

Pevear, D.C., Calenoff, M., Rozhon, E. and Lipton, H.L. (1987). Analysis of the complete nucleotide sequence of the picornavirus Theiler's murine encephalomyelitis virus indicates that it is closely related to cardioviruses. J. Virol. 61: 1507-1516.

Pevear, D.C., Borkowski, J., Calenoff, M., Oh, C.K., Ostrowski, B. and Lipton, H.L. (1988). Insights into Theiler's virus neurovirulence based on a genomic comparison of the neurovirulent GDVII and less virulent BeAn strains. Virology 165: 1-12.

Pritchard, A.E., Strom, T., and Lipton, H.L. (1992a). Nucleotide sequence identifies vilyuisk virus as a divergent Theiler's virus. Virology 191: 469-472.

Pritchard, A.E., Calenoff, M.A., Simpson, S., Jensen, K., and Lipton, H.L. (1992b). A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulence. J. Virol. 66: 1951-1958.

Species: Theilovirus

Theiler's murine encephalomyelitis virus (TMEV)

Vilyuisk human encephalomyelitis virus (VHEV)

Thera virus (TRV) [formerly known as Theiler-like virus (TLV) of rats]

Saffold virus 1 (SAFV-1)

Saffold virus 2 (SAFV-2)

References