| |
Genus: Cardiovirus
Species: Theilovirus
| Type: Theiler's murine encephalomyelitis virus (TMEV) |
|
| 5'
UTR |
L |
VP4 |
VP2 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3'
UTR |
|
| Type: Vilyuisk human encephalomyelitis virus (VHEV)
|
|
| 5'
UTR |
L |
VP4 |
VP2 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3'
UTR |
|
| Type: Thera virus (TRV) |
|
| 5'
UTR |
L |
VP4 |
VP2 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3'
UTR |
|
| Type: Saffold virus 1 (SAFV-1) |
|
| 5'
UTR |
L |
VP4 |
VP2 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3' UTR |
|
| Type: Saffold virus 2 (SAFV-2) |
|
|
5'
UTR |
L |
VP4 |
VP2 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3'
UTR |
|
| Type: Saffold virus 3 (SAFV-3) |
|
| 5'
UTR |
L |
VP4 |
VP2 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3' UTR |
|
| Type: Saffold virus 4 (SAFV-4) |
|
|
5'
UTR |
L |
VP4 |
VP2 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3'
UTR |
|
| Type: Saffold virus 5 (SAFV-5) |
|
|
5'
UTR |
L |
VP4 |
VP2 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3'
UTR |
|
| Type: Saffold virus 6 (SAFV-6) |
|
|
5'
UTR |
L |
VP4 |
VP2 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3'
UTR |
|
| Type: Saffold virus 7 (SAFV-7) |
|
|
5'
UTR |
L |
VP4 |
VP2 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3'
UTR |
|
| Type: Saffold virus 8 (SAFV-8) |
|
|
5'
UTR |
L |
VP4 |
VP2 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3'
UTR |
|
| Type: Saffold virus 9 (SAFV-9) |
|
|
5'
UTR |
L |
VP4 |
VP2 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3'
UTR |
|
(White areas indicate genes which haven't yet been
sequenced completely;
grey areas are where only partial sequences exist)
| Virus |
Strain |
Region |
Length |
Accession No. |
Reference |
Comments |
|
|
| TMEV |
GD VII (New York/37) |
3C+3D+3' NCR |
1924 |
M14703 |
Ozden et al., 1986 |
|
| CG |
8105 |
M20562 |
Pevear et al., 1988 |
|
| CG |
8101 |
X56019 |
Law et al., 1990 |
|
| TMEV |
DA (Boston/52) |
CG |
8093 |
M20301 |
Ohara et al., 1988 |
|
| TMEV |
BeAn 8386 (Brazil/57) |
CG |
8098 |
M16020 |
Pevear et al., 1987 |
|
| TMEV |
M2 (from BeAn 8386) |
L+P1 |
2766 |
AF030574 |
Kim et al.,
1998 |
low-pathogenic M2 variant of strain BeAn 8386 |
| TMEV |
S2 (variant of BeAn 8386) |
CG |
8100 |
DQ401688 |
Myoung et al., 2007 |
|
| TMEV |
TO4 (New York/37) |
5'NCR(p) |
534 |
M80885 |
Pritchard et al., 1992b |
|
| L+P1 |
2760 |
U33045 |
Michiels et al., 1995 |
|
| TMEV |
TO4 (B15) |
5'NCR(p) |
521 |
M80886 |
Pritchard et al., 1992b |
|
| CG |
8100 |
EU718732 |
Liang et al., 2008 |
|
| TMEV |
FA (New York/37) |
5'NCR(p) |
532 |
M80883 |
Pritchard et al., 1992b |
|
| L+P1 |
2766 |
U32924 |
Michiels et al., 1995 |
|
| TMEV |
TO Yale (1943) |
5'NCR(p) |
529 |
M80890 |
Pritchard et al., 1992b |
|
| L+P1 |
2766 |
U33047 |
Michiels et al., 1995 |
|
| CG |
8096 |
EU723238 |
Liang et al., 2008 |
|
| TMEV |
WW (Philadelphia/77) |
5'NCR(p) |
534 |
M80889 |
Pritchard et al., 1992b |
|
| L+P1 |
2760 |
U33046 |
Michiels et al., 1995 |
|
| TMEV |
VL |
5'NCR+L(p) |
1100 |
M80887 |
Pritchard et al., 1992b |
|
| TMEV |
ASK-1 |
P1 |
2649 |
U20288 |
Luo et al., unpublished |
|
| TMEV |
? |
5'UTR(p) |
58 |
S61105 |
Bandyopadhyay et al., 1993 |
|
| TMEV |
MHG* |
5'NCR(p)+L(p) |
521 |
M80884 |
Pritchard et al., 1992b |
|
| TMEV |
Vie415HTR |
CG |
8096 |
EU718733 |
Liang et al., 2008 |
|
|
|
| VHEV |
V1/Siberia/55 |
5' NCR(p) |
966 |
M80888 |
Pritchard et al., 1992b |
|
| L+P1 |
2790 |
M94868 |
Pritchard et al., 1992a |
|
| P2+P3+3'UTR |
4286 |
EU723237 |
Liang et al., 2008 |
|
|
|
| TRV |
NGS910 |
CG |
8021 |
AB090161 |
Ohsawa et al., 2003 |
5' end missing (~73 nt) |
| TRV |
RTV1† |
CG |
7996 |
EU815052 |
Doel et al., unpublished |
5' end missing (~100 nt) |
| TRV |
RTV1† |
CG |
8094 |
EU542581 |
Drake et al., 2008 |
|
|
|
| SAFV-1 |
California/81 |
CG |
8115 |
EF165067 |
Jones et al., 2007 |
|
| SAFV-1 |
LZ50419 |
5'UTR(p) |
778 |
FJ586238 |
Xu et al., 2009 |
China: Oct-2006 |
| VP1 |
896 |
FJ586240 |
Xu et al., 2009 |
| SAFV-1 |
GL311
|
VP1 |
825 |
FJ464766 |
Ren et al., 2009 |
China: Nov-2007 |
| SAFV-1 |
GL317 |
VP1 |
825 |
FJ464767 |
Ren et al., 2009 |
China: Nov-2007 |
| SAFV-1 |
GL328 |
VP1 |
825 |
FJ464768 |
Ren et al., 2009 |
China: Nov-2007 |
| SAFV-1 |
GL341 |
VP1 |
825 |
FJ464769 |
Ren et al., 2009 |
China: Nov-2007 |
| SAFV-1 |
GL352 |
VP1 |
825 |
FJ464770 |
Ren et al., 2009 |
China: Nov-2007 |
| SAFV-1 |
GL361 |
VP1 |
825 |
FJ464771 |
Ren et al., 2009 |
China: Nov-2007 |
| SAFV-1 |
GL362 |
VP1 |
825 |
FJ464772 |
Ren et al., 2009 |
China: Nov-2007 |
| SAFV-1 |
GL365 |
VP1 |
825 |
FJ464773 |
Ren et al., 2009 |
China: Nov-2007 |
| SAFV-1 |
GL368
|
VP1 |
825 |
FJ464774 |
Ren et al., 2009 |
China: Nov-2007 |
| SAFV-1 |
GL371
|
VP1 |
825 |
FJ464775 |
Ren et al., 2009 |
China: Nov-2007 |
| SAFV-1 |
GL376
|
VP1 |
825 |
FJ464776 |
Ren et al., 2009 |
China: Nov-2007 |
| SAFV-1 |
GL377
|
VP1 |
825 |
FJ464777 |
Ren et al., 2009 |
China: Nov-2007 |
|
|
| SAFV-2 |
Can112051-06 |
pp-coding
region |
6882 |
AM922293 |
Abed and Boivin, 2008 |
Canada: 06-Mar-2006 |
| SAFV-2 |
UC1 |
CG |
7961 |
EU376394 |
Chiu et al., 2008 |
approx. 90 nt missing from 5' end |
| SAFV-2 |
UC3 |
5'UTR(p) |
607 |
EU604742 |
Chiu et al., 2008 |
|
| VP1 |
819 |
EU604750 |
Chiu et al., 2008 |
|
|
SAFV-2 |
UC4 |
5'UTR(p) |
608 |
EU604739 |
Chiu et al., 2008 |
|
| VP1 |
819 |
EU604747 |
Chiu et al., 2008 |
|
|
SAFV-2 |
UC6 |
5'UTR(p) |
607 |
EU604744 |
Chiu et al., 2008 |
|
| VP1 |
819 |
EU604748 |
Chiu et al., 2008 |
|
|
SAFV-2 |
UC7 |
5'UTR(p) |
607 |
EU604743 |
Chiu et al., 2008 |
|
| VP1 |
819 |
EU604749 |
Chiu et al., 2008 |
|
| SAFV-2 |
D/VI2229/2004 |
P1 |
2532 |
EU681176 |
Drexler et al., 2008 |
Germany |
| SAFV-2 |
BR/118/2006 |
P1 |
2532 |
EU681177 |
Drexler et al., 2008 |
Brazil |
|
SAFV-2 |
Pak971 |
VP1 |
816 |
FJ463601 |
Blinkova et al.,
2009 |
Pakistan: 05-Mar-2008 |
| 2C(p) |
220 |
FJ463607 |
Blinkova et al.,
2009 |
| SAFV-2 |
FIN08-13B |
VP3(p)+VP1+2A(p) |
1181 |
FJ374267 |
Blomqvist et al.,
unpub. |
|
|
|
| SAFV-3 |
D/VI2273/2004 |
P1 |
2538 |
EU681178 |
Drexler et al., 2008 |
Germany |
| SAFV-3 |
D/VI2223/2004 |
P1 |
2538 |
EU681179 |
Drexler et al., 2008 |
Germany |
| SAFV-3 |
UC2 |
5'UTR(p) |
607 |
EU604741 |
Chiu et al., 2008 |
|
| VP1 |
813 |
EU604745 |
Chiu et al., 2008 |
|
| SAFV-3 |
UC5 |
5'UTR(p) |
607 |
EU604740 |
Chiu et al., 2008 |
|
| VP1 |
813 |
EU604746 |
Chiu et al., 2008 |
|
| SAFV-3 |
Pak2678 |
VP1 |
810 |
FJ463605 |
Blinkova et al., 2009 |
|
| 2C(p) |
220 |
FJ463612 |
Blinkova et al., 2009 |
| SAFV-3 |
Nig266 |
VP1(p) |
723 |
FJ997531 |
Blinkova, unpub. |
Nigeria: March 2007 |
| 2C(p) |
220 |
FJ997534 |
Blinkova, unpub. |
| SAFV-3 |
Nijmegen2007 |
CG |
8051 |
FM207487 |
Zoll et al., 2009 |
Netherlands, 05-Dec-2007 |
| SAFV-3 |
07-Aichi10247 |
VP1 |
813 |
AB542806 |
Ito and Yamashita, unpub. |
Japan: 2007 |
| SAFV-3 |
07-Aichi10345 |
VP1 |
813 |
AB542807 |
Ito and Yamashita, unpub. |
Japan: 2007 |
|
|
|
SAFV-4 |
Pak5842 |
VP1 |
813 |
FJ463606 |
Blinkova et al., 2009 |
|
| 2C(p) |
220 |
FJ463611 |
Blinkova et al., 2009 |
|
SAFV-4 |
Pak12 |
VP1 |
813 |
FJ463600 |
Blinkova et al., 2009 |
|
| 2C(p) |
220 |
FJ463610 |
Blinkova et al., 2009 |
|
SAFV-4 |
Pak962 |
VP1 |
813 |
FJ463603 |
Blinkova et al., 2009 |
|
| 2C(p) |
220 |
FJ463608 |
Blinkova et al., 2009 |
|
|
| SAFV-5 |
Pak5003 |
CG‡ |
7627 |
FJ463615 |
Blinkova et al., 2009 |
‡, 5' and 3' ends missing |
| SAFV-5 |
Pak5152 |
CG‡ |
7639 |
FJ463616 |
Blinkova et al., 2009 |
‡, 5' and 3' ends missing |
|
|
| SAFV-6 |
Pak6572 |
CG‡ |
7410 |
FJ463617 |
Blinkova et al., 2009 |
‡, 5' and 3' ends missing |
|
|
|
SAFV-7 |
Afg1449 |
VP1 |
816 |
FJ463602 |
Blinkova et al., 2009 |
Afghanistan: 2007 |
| 2C(p) |
220 |
FJ463613 |
Blinkova et al., 2009 |
|
|
|
SAFV-8 |
Pak1141 |
VP1 |
810 |
FJ463604 |
Blinkova et al., 2009 |
Pakistan: 13-Mar-2008 |
| 2C(p) |
220 |
FJ463614 |
Blinkova et al., 2009 |
|
|
| SAFV-9 |
Nig239 |
5'UTR(p)+
L+VP4+VP2(p) |
653 |
FJ997541 |
Blinkova, unpub. |
Nigeria: March 2007 |
| SAFV-9 |
Nig329? |
VP1(p) |
789 |
FJ997532 |
Blinkova, unpub. |
Nigeria: March 2007 |
| SAFV-9 |
Nig239 |
2C(p) |
220 |
FJ997535 |
Blinkova, unpub. |
Nigeria: March 2007 |
|
|
| SAFV-? |
LZ52903 |
5'UTR(p) |
536 |
FJ610244 |
Xu et al., 2009 |
China: June 2007 |
| SAFV-? |
LZ53879 |
5'UTR(p) |
538 |
FJ623968 |
Xu et al., 2009 |
China: 28-Sep-2007 |
| SAFV-? |
LZ53010 |
5'UTR(p) |
538 |
FJ586239 |
Xu et al., 2009 |
China: 28-Oct 2006 |
| SAFV-? |
Pak9 |
2C(p) |
220 |
FJ463609 |
Blinkova et al., 2009a |
Pakistan: 17-Apr-2008 |
| SAFV-? |
Nig234 |
2C(p) |
220 |
FJ997533 |
Blinkova, unpub. |
Nigeria: March 2007 |
| SAFV-? |
Tun-S88 |
2C(p) |
220 |
FJ997536 |
Blinkova, unpub. |
Tunisia: 2005 |
| SAFV-? |
Tun-S305 |
2C(p) |
220 |
FJ997537 |
Blinkova, unpub. |
Tunisia: 2005 |
| SAFV-? |
Tun-S239 |
2C(p) |
220 |
FJ997538 |
Blinkova, unpub. |
Tunisia: 2006 |
| SAFV-? |
Tun-S90 |
2C(p) |
220 |
FJ997539 |
Blinkova, unpub. |
Tunisia: 2008 |
| SAFV-? |
Tun-S105 |
2C(p) |
220 |
FJ997540 |
Blinkova, unpub. |
Tunisia: 2008 |
| SAFV-? |
FL1-2 |
2C(p) |
188 |
GQ243683 |
Blinkova et al., 2009b |
USA: 30-Nov-2007 |
| SAFV-? |
FL2-3 |
2C(p) |
188 |
GQ243684 |
Blinkova et al., 2009b |
USA: 01-Oct-2008 |
| SAFV-? |
FL2-4 |
2C(p) |
188 |
GQ243685 |
Blinkova et al., 2009b |
USA: 04-Oct-2008 |
| SAFV-? |
FL2-5 |
2C(p) |
188 |
GQ243686 |
Blinkova et al., 2009b |
USA: 06-Oct-2008 |
| SAFV-? |
FL2-6 |
2C(p) |
188 |
GQ243687 |
Blinkova et al., 2009b |
USA: 08-Oct-2008 |
| SAFV-? |
FL2-7 |
2C(p) |
188 |
GQ243688 |
Blinkova et al., 2009b |
USA: 11-Oct-2008 |
| SAFV-? |
FL2-1 |
2C(p) |
188 |
GQ243689 |
Blinkova et al., 2009b |
USA: 07-Dec-2008 |
| SAFV-? |
NC-1 |
2C(p) |
188 |
GQ243690 |
Blinkova et al., 2009b |
USA: 13-Nov-2007 |
| SAFV-? |
CA-1 |
2C(p) |
188 |
GQ243691 |
Blinkova et al., 2009b |
USA: 18-Oct-2007 |
| |
|
|
|
|
|
|
* also known as rat encephalomyelitis virus.
†, the authors refer to this as rat theilovirus 1.
‡, 5' and 3' ends missing.
CG = complete genome; (p) = partial gene sequence. |
Abed, Y. and Boivin, G. (2008). New Saffold cardioviruses in 3
children, Canada. Emerging Infectious Diseases 14: 834-836.
Bandyopadhyay, P.K., Pritchard, A., Jensen, K. and Lipton, H.L. (1993). A
three-nucleotide insertion in the H stem-loop of the 5' untranslated region of
Theiler's virus attenuates neurovirulence. J. Virol. 67: 3691-3695.
Blinkova, O., Kapoor, A., Victoria, J., Jones, M.,
Wolfe, N., Naeem, A., Shaukat, S., Sharif, S., Alam, M.M., Angez, M.,
Zaidi, S. and Delwart, E.L. (2009a). Cardioviruses are genetically
diverse and cause common enteric infections in South Asian children. J.
Virol. 83: 4631-4641.
Blinkova, O., Rosario, K., Li, L., Kapoor, A., Slikas,
B., Bernardin, F., Breitbart, M. and Delwart, E. (2009b). Frequent
detection of highly diverse variants of cardiovirus, cosavirus,
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Myoung, J., Hou, W., Kang, B., Lyman, M.A., Kang, J.-A.
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