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Child level |
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Genera |
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| Cosavirus (formerly called
Dekavirus) is a newly
described candidate picornavirus genus consisting of viruses
identified in the stools of south Asian children (Kapoor et al.,
2008). The authors suggest, by comparison with human enteroviruses,
that there may be four distinct human cosavirus (HCoSV) species,
which they name HCoSV-A to -D. Cosaviruses are most closely related
to members of the
Cardiovirus and
Senecavirus
genera, but they lack a leader polypeptide. They possess an 2A NPG¯P
motif, which may or may not be cleaved from VP1. A second putative
2A is not related to any other picornavirus 2A. An unusually long
(1,164 nt) 5' UTR contains a type II IRES. A fifth candidate human
cosavirus species (designated HCoSV-E) has recently been described
(Holtz et al., 2008). Derivation of name: Cosavirus is from common stool-associated picornavirus. References Holtz, L.R., Finkbeiner, S.R., Kirkwood, C.D. and Wang, D. (2008). Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea. Virology Journal 5: 159; doi:10.1186/1743-422X-5-159. Kapoor, A., Victoria, J., Simmonds, P., Slikas, E., Chieochansin, T., Naeem, A., Shaukat, S., Sharif, S., Masroor Alam, M., Angez, M., Wang, C., Shafer, R.W., Zaidi, S. and Delwart, E. (2008). A highly prevalent and genetically diversified Picornaviridae genus in South Asian children. Proc. Natl. Aad. Sci., USA 105: 20482-20487. doi 10.1073 pnas.0807979105. |