The
Picornavirus
Pages
 Cosavirus

Child level

Cosavirus A
Cosavirus B
Cosavirus D
Cosavirus E
Cosavirus F
Unassigned cosaviruses

Same level

Home
Genus supergroups
Alphabetical List
Hosts
New picornaviruses
Ampivirus
Aphthovirus
Aquamavirus
Avihepatovirus
Avisivirus
Cardiovirus
Cosavirus
Dicipivirus
Enterovirus
Erbovirus
Gallivirus
Harkavirus
Hepatovirus
Hunnivirus
Kobuvirus
Kunsagivirus
Limnipivirus
Megrivirus
Mischivirus
Mosavirus
Oscivirus
Parechovirus
Pasivirus
Passerivirus
Potamipivirus
Rabovirus
Rosavirus
Sakobuvirus
Salivirus
Sapelovirus
Senecavirus
Sicinivirus
Teschovirus
Torchivirus
Tremovirus
Proposed new taxa
Unassigned PV
Candidate PV
Search for New Picornaviruses
Former picornaviruses
Taxonomy guidelines
Sequences
3-D Structures
Links

Genera

"Ampivirus"
Aphthovirus
Aquamavirus
Avihepatovirus
Avisivirus
Cardiovirus
Cosavirus
Dicipivirus
Enterovirus
Erbovirus
Gallivirus
"Harkavirus"
Hepatovirus
Hunnivirus
Kobuvirus
Kunsagivirus
Limnipivirus
Limnipivirus
Megrivirus
Mischivirus
Mosavirus
Oscivirus
Parechovirus
Pasivirus
Passerivirus
Potamipivirus
"Rabovirus"
Rosavirus
Sakobuvirus
Salivirus
Sapelovirus
Senecavirus
Sicinivirus
Teschovirus
"Torchivirus"
Tremovirus
Unassigned
  The genus Cosavirus consists of five species Cosavirus A, Cosavirus B, Cosavirus D, Cosavirus E and Cosavirus F. The candidate species, 'Cosavirus C', remains unclassified due to a lack of full genome sequence data.

Cosaviruses (formerly called Dekaviruses) have been identified in the stools of south Asian children (Kapoor et al., 2008; Holtz et al., 2008; Kapusinszky et al., 2012). Cosaviruses are most closely related to members of the Cardiovirus and Senecavirus genera, but they lack a leader polypeptide. They possess an 2A NPGP motif, which may or may not be cleaved from VP1. An unusually long (1,164 nt) 5' UTR contains a type II IRES.

Derivation of name: Cosavirus is from common stool-associated picornavirus.

Genome organisation:

VPg+5'UTRIRES-II[1A-1B-1C-1D-2Anpgp/2B-2C/3A-3BVPg-3Cpro-3Dpol]3'UTR-poly(A)

Search of Cosavirus sequences on GenBank

References

Holtz, L.R., Finkbeiner, S.R., Kirkwood, C.D. and Wang, D. (2008). Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea. Virology Journal 5: 159; doi:10.1186/1743-422X-5-159.

Kapoor, A., Victoria, J., Simmonds, P., Slikas, E., Chieochansin, T., Naeem, A., Shaukat, S., Sharif, S., Masroor Alam, M., Angez, M., Wang, C., Shafer, R.W., Zaidi, S. and Delwart, E. (2008). A highly prevalent and genetically diversified Picornaviridae genus in South Asian children. Proc. Natl. Aad. Sci., USA 105: 20482-20487. doi 10.1073 pnas.0807979105.

Kapusinszky, B., Phan, T.G., Kapoor, A. and Delwart, E. (2012). Genetic diversity of the genus Cosavirus in the family Picornaviridae: a new species, recombination, and 26 new genotypes. PLoS One. 7(5):e36685. Epub 2012 May 16.