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 Cosavirus

Child level

Cosavirus A
Cosavirus B
Cosavirus D
Cosavirus E
Cosavirus F
Unassigned cosaviruses

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Unassigned
  The genus Cosavirus consists of five species Cosavirus A, Cosavirus B, Cosavirus D, Cosavirus E and Cosavirus F. The candidate species, 'Cosavirus C', remains unclassified due to a lack of full genome sequence data.

Cosaviruses (formerly called Dekaviruses) have been identified in the stools of south Asian children (Kapoor et al., 2008; Holtz et al., 2008; Kapusinszky et al., 2012). Cosaviruses are most closely related to members of the Cardiovirus and Senecavirus genera, but they lack a leader polypeptide. They possess an 2A NPGP motif, which may or may not be cleaved from VP1. An unusually long (1,164 nt) 5' UTR contains a type II IRES.

Derivation of name: Cosavirus is from common stool-associated picornavirus.

Genome organisation:

VPg+5'UTRIRES-II[1A-1B-1C-1D-2Anpgp/2B-2C/3A-3BVPg-3Cpro-3Dpol]3'UTR-poly(A)

Search of Cosavirus sequences on GenBank

References

Holtz, L.R., Finkbeiner, S.R., Kirkwood, C.D. and Wang, D. (2008). Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea. Virology Journal 5: 159; doi:10.1186/1743-422X-5-159.

Kapoor, A., Victoria, J., Simmonds, P., Slikas, E., Chieochansin, T., Naeem, A., Shaukat, S., Sharif, S., Masroor Alam, M., Angez, M., Wang, C., Shafer, R.W., Zaidi, S. and Delwart, E. (2008). A highly prevalent and genetically diversified Picornaviridae genus in South Asian children. Proc. Natl. Aad. Sci., USA 105: 20482-20487. doi 10.1073 pnas.0807979105.

Kapusinszky, B., Phan, T.G., Kapoor, A. and Delwart, E. (2012). Genetic diversity of the genus Cosavirus in the family Picornaviridae: a new species, recombination, and 26 new genotypes. PLoS One. 7(5):e36685. Epub 2012 May 16.