"Turkey hepatitis virus"

Child level

Same level

Genera

The proposed species "Turkey hepatitis virus" is the type species of the proposed genus "Megrivirus".

A novel picornavirus has recently been identified as the probable cause of hepatitis in turkeys (Honkavuori et al., 2011). Turkey hepatitis virus 1 (THV-1) has a genome of >9,040 nt and a predicted polyprotein of 2,813 aa making it the longest picornavirus genome so far described. The 5' (461 nt) and 3' (173 & 136 nt) UTRs were incomplete.

Similar partial genome sequences (partial 3D and 3' UTR) have recently been detected in turkeys and chickens (Farkas et al., 2011). These sequences show the 3' UTR of THV to be 641-654 nt in length, the longest picornavirus 3' UTR so far described.

Viral Hepatitis of Turkeys (Merck Veterinary Manual).

Genome organisation:

VPg+5'UTR^IRES-IV?[1AB-1C-1D/2A?-2A?-2A^H-box/NC-2B-2C/3A-3B^VPg-3C^pro-3D^pol]3'UTR-poly(A)

References

Farkas, T., Fey, B., Hargitt 3rd, E., Parcells, M., Ladman, B., Murgia, M. and Saif, Y. (2011). Molecular detection of novel picornaviruses in chickens and turkeys. Virus Genes. 2011 Dec 13.

Honkavuori, K.S., Shivaprasad, H.L., Briese, T., Street, C., Hirschberg, D.L, Hutchison, S.K. and Lipkin, W.I. (2011). Novel picornavirus in turkey poults with hepatitis, California, USA. Emerg. Infect. Dis. 17: 480-487.

Klein, P.N., Castro, A.E., Meteyer, C.U., Reynolds, B., Swartzman-Andert, J.A., Cooper, G., Chin, R.P. and Shivaprasad, H.L. (1991). Experimental transmission of turkey viral hepatitis to day-old poults and identification of associated viral particles resembling picornaviruses. Avian Diseases 35: 115-125.

MacDonald, J.W., Randall, C.J., Dagless, M.D. and Gray, E.W. (1982). Picorna- like virus causing hepatitis and pancreatitis in turkeys. Vet. Rec. 111: 323.

Shivaprasad, H.L., Honkavuori, K.S., Briese, T. and Lipkin, W.I. (2010). A novel picornavirus associated with turkey viral hepatitis. Presented at the 147th American Veterinary Medical Association (AVMA) Annual Convention, Atlanta, Georgia, 31 July to 3 August 2010.

Snoeyenbos, G.H., Bosch, H.I. and Sevoian, M. (1959). An infectious agent producing hepatitis in turkeys. Avian Diseases. 3: 377-388.

Tzianabos, T. and Snoeyenbos, G.H. (1965). Clinical. Immunological and serological observations on turkeys virus hepatitis. Avian Diseases 9: 578-591.