| |
Genus: Parechovirus
Species: Ljungan virus
| Type: Ljungan virus 1 (LV-1) |
|
| 5'
UTR |
VP0 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3'
UTR |
|
| Type: Ljungan virus 2 (LV-2) |
|
| 5'
UTR |
VP0 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3'
UTR |
|
| Type: Ljungan virus 3 (LV-3) |
|
| 5'
UTR |
VP0 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3'
UTR |
|
| Type: Ljungan virus 4 (LV-4) |
|
| 5'
UTR |
VP0 |
VP3 |
VP1 |
2A |
2B |
2C |
3A |
3B |
3C |
3D |
3'
UTR |
|
| |
|
|
(White areas indicate genes which haven't yet been
sequenced completely;
grey areas are where only partial sequences exist)
| Virus |
Strain |
Region |
Length
|
Accession No. |
Reference |
Comments |
|
|
|
LV-1 |
87-012 |
CG |
7607 |
AF327920 |
Johansson et al.,
2002 |
5' end missing; host:
bank vole (Myodes
glareolus) |
| LV-1 |
87-012G |
CG |
7635 |
EF202833 |
Johansson et al.,
2004;
Ekstrom et al., 2007 |
cell culture adapted 87-012 |
|
LV-1 |
174F |
CG |
7608 |
AF327921 |
Johansson et al.,
2002 |
5' end missing; host: bank
vole (Myodes
glareolus) |
|
|
| LV-2 |
145SL |
5'UTR(p)+
VP0+VP3 |
2118
|
AF020541 |
Niklasson et al., 1998 |
host: bank vole (Myodes
glareolus) |
|
CG |
7592 |
AF327922 |
Johansson et al.,
2002 |
5' end missing |
|
LV-2 |
145SLG |
CG |
7637 |
FJ384560 |
Tolf et al., 2009b |
cell culture adapted 145SL |
|
|
|
LV-3 |
M1146 |
CG |
7495 |
AF538689 |
Johansson et al.,
2003 |
94 nt missing from 5' end;
host:
montane vole (Microtus montanus) |
|
|
| LV-4 |
64-7855 |
CG |
7436 |
EU854568 |
Tolf et al., 2009a |
incomplete at 5' end;
host: southern
red-backed vole (Myodes gapperi) |
|
|
| LV-? |
RKI1 |
5'UTR(p) |
187 |
FJ184039 |
Kallies et al., unpub. |
host: Rattus norvegicus |
| LV-? |
RKI2 |
5'UTR(p) |
187 |
FJ184040 |
Kallies et al., unpub. |
host: Rattus norvegicus |
|
CG = complete genome; (p) = partial gene sequence |
Ekstrom, J.O., Tolf, C., Fahlgren, C., Johansson, E.S.,
Arbrandt, G., Niklasson, B., Edman, K.A. and Lindberg, A.M. (2007). Replication
of Ljungan virus in cell culture: The genomic 5'-end, infectious cDNA clones and
host cell response to viral infections Virus Res. 130: 129-139.
Johansson, S., Niklasson,
B., Maizel, J. Gorbalenya, A.E. and Lindberg,
A.M. (2002). Molecular analysis of three Ljungan
virus isolates reveals a new, close-to-root lineage of the Picornaviridae
with a cluster of two unrelated 2A proteins.J. Virol. 76: 8920-8930.
Johansson, E.S., Niklasson, B., Tesh, R.B., Shafren, D.R., Travassos Da Rosa,
A.P.A. and Lindberg, A.M. (2003). Molecular characterization of M1146, an
American isolate of Ljungan virus (LV) reveals the presence of a new LV
genotype. J. Gen. Virol. 84: 837-844.
Johansson, E.S., Ekstrom, J.-O., Shafren, D.R.,
Frisk, G., Hyypia, T., Edman, K. and Lindberg, A.M. (2004).
Cell culture propagation and biochemical analysis of the Ljungan
virus prototype strain Biochem. Biophys. Res. Commun. 317:
1023-1029.
Niklasson, B., Kinnunen, L., Hornfeldt, B., Horling, J., Benemar, C., Hedlund, K.O.,
Matskova, L., Hyypiä, T. and Winberg, G. (1999). A new picornavirus isolated from bank
voles (Clethrionomys glareolus). Virology 255: 86-93.
Tolf, C., Gullberg, M., Johansson, E.S., Tesh,
R.B., Andersson, B. and Lindberg, A.M. (2009a). Molecular
characterization of a novel Ljungan virus (Parechovirus;
Picornaviridae) reveals a fourth genotype and indicates
ancestral recombination. J Gen Virol. 90: 843-653. Epub 2009 Mar 4.
Tolf, C., Gullberg, M., Ekstrom, J.O., Jonsson, N.
and Michael Lindberg, A. (2009b). Identification of amino acid
residues of Ljungan virus VP0 and VP1 associated with cytolytic
replication in cultured cells. Arch. Virol. 154: 1271-1284.
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