Parechovirus A

Child level

Parechovirus A seqs

Same level

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Parechovirus A
Parechovirus B
Parechovirus C
Parechovirus D
Ljungan/Sebokele-like parechovirus
Manhatten parechovirus

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Unassigned
 

The species Parechovirus A (formerly named Human parechovirus) consists of 19 types, human parechovirus (HPeV)-1 to 19. HPeV-1 and HPeV-2, were formerly classified in the enterovirus genus as echovirus 22 and 23, respectively. Another isolate, CT86-6760, originally classified as E-23/HPeV-2 (based on serological cross-reactions) has been re-classified as HPeV-5.

Search for Human parechovirus sequences on GenBank

Genome organisation

VPg+5'UTRIRES-II[1AB-1C-1D/2A
H-Box/NC-2B-2C/3A-3BVPg-3Cpro-3Dpol]3'UTR-poly(A)

Prototype strains

Type Strain Accession Reference
HPeV-1 Harris L02971 Hyypiä et al., 1992
HPeV-2 Williamson AJ005695 Ghazi et al., 1998
HPeV-3 A308/99 AB084913 Ito et al., 2004
HPeV-4 K251176-02 DQ315670 Benschop et al., 2006
HPeV-5 CT86-6760 AF055846 Oberste et al., 1998
HPeV-6 NII561-2000 AB252582 Watanabe et al., 2007
HPeV-7 PAK5045 EU556224 Li et al., 2009
HPeV-8 BR/217/2006 EU716175 Drexler et al., 2009
HPeV-9 BAN2004-10902 JX219575 Nix et al., 2013
HPeV-10 BAN2004-10903 X219568 Nix et al., 2013
HPeV-11 BAN2004-10905 JX219574 Nix et al., 2013
HPeV-12 BAN2004-10904 JX219567 Nix et al., 2013
HPeV-13 BAN2005-10901 JX219579 Nix et al., 2013
HPeV-14 451564 (NL, 2004) FJ373179 Benschop et al., 2008
HPeV-15 BAN-11614 JX219573 Nix et al., 2013
HPeV-16 BAN-11615 JX219580 Nix et al., 2013
HPeV-17 M36/CI/2014 KT319121 Böttcher et al., 2017
HPeV-18 GhanaA36 886 KY931660 Graul et al., 2017
HPeV-19 17-827 n/a Böttcher et al., unpub.

References

Abed, Y. and Boivin, G. (2005). Molecular characterization of a Canadian human parechovirus (HPeV)-3 isolate and its relationship to other HPeVs. J. Med. Virol. 77: 566-570.

Al-Sunaidi, M., Williams, C.H., Hughes, P.J., Schnurr, D.P. and Stanway G. (2006). Analysis of a new human parechovirus allows the definition of parechovirus types and the identification of RNA structural domains. J. Virol. Sep 27; [Epub ahead of print]

Benschop, K.S.M., Schinkel, J., Luken, M.E., van den Broek, P.J.M., Beersma, M.F.C., Menelik, N., van Eijk, H.W.M., Zaaijer, H.L., VandenBroucke-Grauls, C.M.J.E., Beld, M.G.H.M. and Wolthers, K.C. (2006). Fourth human parechovirus serotype. Emerging Infect. Dis. 12, 1572-1575.

Benschop, K., Thomas, X., Serpenti, C., Molenkamp, R. and Wolthers, K. (2008). High prevalence of human parechovirus (HPeV) genotypes in the Amsterdam region and identification of specific HPeV variants by direct genotyping of stool samples. J. Clin. Microbiol. 46: 3965-3970. Epub 2008 Oct 22.

Böttcher, S., Obermeier, P.E., Diedrich, S., Kaboré, Y., D'Alfonso, R., Pfister, H., Kaiser, R. and Di Cristanziano, V. (2017). Genome sequence of novel human parechovirus type 17. Genome Announc. 5(8). pii: e01649-16.

Drexler, J.F., Grywna, K., Stöcker, A., Silva Almeida, P., Medrado Ribeiro, T.C., Eschbach-Bludau, M. Petersen, N., da Costa Ribeiro, Jr., H. and Drosten, C. (2009). Novel human parechovirus from Brazil. Emerg. Infect. Dis. 15: 310-313. [DOI: 10.3201/eid1502.081028].

Ghazi, F., Hughes, P.J., Hyypiä, T. and Stanway, G. (1998). Molecular analysis of human parechovirus 2 (formerly echovirus 23). Journal of General Virology 79: 2641-2650.

Graul S, Böttcher S, Eibach D, Krumkamp R, Käsmaier J, Adu-Sarkodie Y, May J, Tannich E, Panning M. High diversity of human parechovirus including novel types in stool samples from Ghanaian children. J Clin Virol. 2017 Nov;96:116-119. doi: 10.1016/j.jcv.2017.10.008. Epub 2017 Oct 18. PubMed PMID: 29055866.

Hyypiä, T., Horsnell, C., Maaronen, M., Khan, M., Kalkkinen, N., Auvinen, P., Kinnunen, L. and Stanway, G. (1992). A distinct picornavirus group identified by sequence analysis. Proc. Natl. Acad. Sci., U.S.A. 89: 8847-8851.

Ito, M., Yamashita, T., Tsuzuki, H., Takeda, N. and Sakae, K. (2004). Isolation and identification of a novel human parechovirus. J. Gen. Virol. 85: 391-398.

Li, L., Victoria, J., Kapoor, A., Naeem, A., Shaukat, S., Sharif, S., Alam, M.M., Angez, M., Zaidi, S.Z. and Delwart, E. (2009). Genomic characterization of a novel human parechovirus type. Emerg. Infect. Dis. 15: 288-291 [DOI: 10.3201/eid1502.080341].

Manzara, S., Muscillo, M., La Rosa, G., Marianelli, C., Cattani, P. and Fadda, G. Biological and molecular characterization of human enteroviruses. Unpublished. [Environmental Hygiene, Istituto Superiore di Sanita', Viale Regina Elena 299, Rome, RM 00199, Italy]

Nix, W.A., Khetsuriani, N., Peñaranda, S., Maher, K., Venczel, L., Cselkó, Z., Freire, M.C., Cisterna, D., Lema, C.L., Rosales, P., Rodriguez, J.R., Rodriguez, W., Halkyer, P., Ronveaux, O., Pallansch, M.A. and Oberste, M.S. (2013). Diversity of picornaviruses in rural Bolivia. J. Gen. Virol. 94: 2017-2028.

Oberste, M.S., Maher, K. and Pallansch, M.A. (1998). Complete sequence of echovirus 23 and its relationship to echovirus 22 and other human enteroviruses. Virus Research 56: 217-223.

Stanway, G., Kalkkinen, N., Roivainen, M., Ghazi, F., Khan, M., Smyth, M., Meurman, O. and Hyypiä, T. (1994). Molecular and biological characteristics of echovirus 22, a representative of a new picornavirus group. J. Virol. 68: 8232-8238.

Watanabe, K., Oie, M., Higuchi, M., Nishikawa, M. and Fujii, M. (2007). Isolation and characterization of novel human parechovirus from clinical samples. Emerg. Infect. Dis. 13: 889-895.