A tick-borne infection occurring in the river valleys of
Kazakhstan. SDF virus was first isolated from the blood of a patient in the
summer of 1973. The virus has also been isolated from Hyalomma asiaticum
ticks in enzootic areas and from Dermacentor daghestanicus ticks. All
documented cases in humans give a history of tick bite.
The onset of illness is abrupt with temperatures of 39-40
°C, shivering, weakness, headache and an extensive roseolar-petechial rash
mainly on the extremities, chest and abdomen.
The Kaz-3 strain was studied by electron
microscopy revealing featureless 25-27 nm virions typical of picornaviruses.
Serologically related to both
Sikhote-Alyn virus and mengovirus (EMCV) by complement fixation but all three are distinct
by cross-neutralization.
References
Karimov, S.K., Lvov, D.K. and Kiryushchenko, T.V. (1989).
Syrdarya Valley fever, a new virus disease in Kazakhstan. In: Arboviruses and
Arboviral Infections. Abstracts book, ed. by D.K. Lvov. from "An International
Symposium on Arboviruses and Arboviral Infections", Moscow, U.S.S.R., October
3-5, 1989.
Karimov, S.K., Lvov, D.K. and Kiryushchenko, T.V. (1990). Syrdarya Valley fever, a new virus disease in Kazakhstan. Arch. Virol., Suppl.
1: 345.
L'vov, D.K., Karimov, S.K., Kiriushchenko, T.V., Chun-Siun,
F., Skvortsova, T.M. (1984). [Isolation of the virus of Syr-Darya Valley
fever] Vopr Virusol. 29: 553-558 (In Russian).
Lvov, D.K. (1994). Arboviral zoonoses of Northern Eurasia
(Eastern Europe and the Commonwealth of Independent States). In: Handbook of
Zoonoses, 2nd Edition, Section B: Viral, Ed. G.W. Beran, CRC Press Inc., Boca
Raton, p. 237-260.
