Sikhote-Alin virus

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Sikhote-Alin virus
TMEV seqs

Sikhote-Alin virus* (SAV)

Isolated from Ixodes persulcatus ticks taken from wild boars (Sus scrofa) in the Krasnoyarsk district of the Primorsky region in the foothills of the mountain range Sikhote-Alin (Russia). The LEIV 113P (or P-113) strain was isolated on 31 July 1970 from a pool of 10 female ticks (Lvov et al., 1978). The virus was labile at pH 3.0, but stable between pH 5.0-7.0. Heating at 50 C inactivated the virus, but thermostability was increased in the presence of 1M MgCl2. The virus was pathogenic for suckling and 2-3 week-old mice, but not for adult mice, rats, hamsters, guinea pigs rabbits or chick embryos. It did not show CPE in four types of cell culture (HEp-2, PEK, HEK, GMK).

Serologically related to both Syr-Darya Valley fever virus and mengovirus (EMCV) by complement fixation but all three are distinct by cross-neutralization.

The recently determined complete genome sequence of SAV P-113 (KJ191558; Alkhovsky et al., unpub.) suggests that it is a TMEV isolate.

*Also spelt Sikhote-Alyn.


Alkhovsky, S.V., Shchetinin, A.M., Lvov, D.K. and Shchelkanov, M.Y., unpublished data.

Lvov, D.K., Leonova, G.N., Gromashevsky, V.L., Shestakov, V.L., Gofman, Y.P., Skvortsova, T.M., Klimenko, S.M., Berezina, L.K., Zakaryan, V.A., Safronov, A.V., Belousova, R.V. (1978). Sikhote-Alin virus, a new member of the cardiovirus group (Picornaviridae) isolated from Ixodes persulcatus ticks in Primorie Region. Acta Virol. 22: 458-463.

Lvov, D.K. (1989). Arboviral infections in the subtropics of the temperate belt of the USSR. In: Arboviruses and Arboviral Infections. Lvov, D.K., Kilmenko, S.M. and Gaidamovich, S. Ya., Eds., Meditsina, Moscow, Chapter 8. (In Russian).

Lvov, D.K. (1994). Arboviral zoonoses of Northern Eurasia (Eastern Europe and the Commonwealth of Independent States). In: Handbook of Zoonoses, 2nd Edition, Section B: Viral, Ed. G.W. Beran, CRC Press Inc., Boca Raton, p. 237-260.

Lvov, D.K., Alkhovsky, S.V., Shchelkanov, M. Yu., Shchetinin, A.M., Deryabin, P.G., Gitelman, A.K., Aristova, V.A. and Botikov, A.G. (2014). Genetic characterization of the Syr-Darya valley fever virus (SDVFV) (Picornaviridae, Cardiovirus) isolated from the blood of the patients and ticks Hyalomma as. asiaticum (Hyalomminae), Dermacentor daghestanicus (Rhipicephalinae) (Ixodidae) and  (Argasidae) in Kazakhstan and Turkmenistan. Vopr Virusol. 59: 15-19. In Russian.


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