Syr-Darya Valley fever virus

Child level

Same level

Bat picorna-like virus
Juruaca virus
Sikhote-Alyn virus
Syr-Darya Valley fever virus

Syr-Darya Valley fever virus (SDFV)

A tick-borne infection occurring in the river valleys of Kazakhstan. SDF virus was first isolated from the blood of a patient in the summer of 1973. The virus has also been isolated from Hyalomma asiaticum ticks in enzootic areas and from Dermacentor daghestanicus ticks. All documented cases in humans give a history of tick bite.

The onset of illness is abrupt with temperatures of 39-40 C, shivering, weakness, headache and an extensive roseolar-petechial rash mainly on the extremities, chest and abdomen.

The Kaz-3 strain was studied by electron microscopy revealing featureless 25-27 nm virions typical of picornaviruses.

Serologically related to both Sikhote-Alyn virus and mengovirus (EMCV) by complement fixation but all three are distinct by cross-neutralization.


Karimov, S.K., Lvov, D.K. and Kiryushchenko, T.V. (1989). Syrdarya Valley fever, a new virus disease in Kazakhstan. In: Arboviruses and Arboviral Infections. Abstracts book, ed. by D.K. Lvov. from "An International Symposium on Arboviruses and Arboviral Infections", Moscow, U.S.S.R., October 3-5, 1989.

Karimov, S.K., Lvov, D.K. and Kiryushchenko, T.V. (1990). Syrdarya Valley fever, a new virus disease in Kazakhstan. Arch. Virol., Suppl. 1: 345.

L'vov, D.K., Karimov, S.K., Kiriushchenko, T.V., Chun-Siun, F., Skvortsova, T.M. (1984). [Isolation of the virus of Syr-Darya Valley fever] Vopr Virusol. 29: 553-558 (In Russian).

Lvov, D.K. (1994). Arboviral zoonoses of Northern Eurasia (Eastern Europe and the Commonwealth of Independent States). In: Handbook of Zoonoses, 2nd Edition, Section B: Viral, Ed. G.W. Beran, CRC Press Inc., Boca Raton, p. 237-260.

Lvov, D.K., Alkhovsky, S.V., Shchelkanov, M. Yu., Shchetinin, A.M., Deryabin, P.G., Gitelman, A.K., Aristova, V.A. and Botikov, A.G. (2014). Genetic characterization of the Syr-Darya valley fever virus (SDVFV) (Picornaviridae, Cardiovirus) isolated from the blood of the patients and ticks Hyalomma as. asiaticum (Hyalomminae), Dermacentor daghestanicus (Rhipicephalinae) (Ixodidae) and  (Argasidae) in Kazakhstan and Turkmenistan. Vopr Virusol. 59: 15-19. In Russian.


Copyright © 2006 - The Pirbright Institute, UK. All Rights Reserved.