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The species Dicipivirus acadici (formerly named Cadicivirus A) consists on a single genotype, canine picodicistrovirus, and has been found in dogs and foxes (Woo et al., 2012). The genome contains two ORFs one encoding the P1 capsid and the second containing P2/P3 regions. Each ORF is translated by its own IRES. It is the first naturally occurring dicisronic picornavirus to be described. A functional dicistronic poliovirus had previously been artificially constructed (Molla et al., 1992).

Origin of name: Canine dicistronic picornavirus.

Genome organisation:

VPg+5'UTR^IRES[1A-1B-1C-1D]IGR^IRES[2A-2B-2C/3A-3B^VPg-3C^pro-3D^pol]3'UTR-poly(A)

IGR, intergenic region
IRES, internal ribosome entry site
[] ORF
/ primary cleavage

References

Molla, A., Jang, S.K., Paul, A.V., Reuer, Q. and Wimmer, E. (1992). Cardioviral internal ribosomal entry site is functional in a genetically engineered dicistronic poliovirus. Nature.  356(6366): 255-257.

Woo, P.C., Lau, S.K., Choi, G.K., Huang, Y., Teng, J.L., Tsoi, H.W., Tse, H., Yeung, M.L., Chan, K.H., Jin, D.Y. and Yuen, K.Y. (2012). Natural occurrence and characterization of two internal ribosome entry site elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamily. J. Virol. 86: 2797-2808. Epub 2011 Dec 28.