Enterovirus struct.

Child level

Same level

Aphthovirus struct.
Cardiovirus struct.
Enterovirus struct.
Hepatovirus struct.
Kobuvirus struct.
Parechovirus struct.
Rhinovirus struct.
Senecavirus struct.
Related structures



VIPERdb - Virus Particle Explorer

Genus: Enterovirus

PV-1 5-fold axis PV-1 2-fold axis PV-1 3-fold axis
PV-1 (2plv) PV-2 (1eah) PV-3 (1pvc)
CVA21 (1z7s) CVB3 (1cov) SVDV (1oop)
CVA9 (1d4m) E1 (1ev1) E7 + DAF (1m11)
E11 (1h8t) E12 + DAF (1upn) BEV-1 (1bev)


Virus PDB no. Description [EMBL accession no.] Reference
PV-1 2plv Poliovirus 1 Mahoney [J02281; V01148; V01149] Hogle et al., 1985
1pov Poliovirus 1 native empty capsid. Heterogen: ligand unidentified experimentally but presumed to be a lipid and modeled as sphingosine Basavappa et al., 1994
1fpt IgG2a FAb fragment (c3) complexed with poliovirus type 1 (Mahoney) fragment (residues 86 - 103)  
1vbd Poliovirus 1 Mahoney complexed with R78206 Grant et al., 1994
1rdr Poliovirus 1 Mahoney - 3D polymerase Hansen et al., 1997
1l1n 3C protease (PV-1 Mahoney)  
PV-2/PV-1 N/A Chimera Yeates et al., 1991
PV-2 1eah Poliovirus 2 Lansing complexed with antiviral agent SCH48973 Lentz et al., 1997
PV-3 1pvc Poliovirus 3 Sabin (P3/Leon/12a(1)b) [K00043] Filman et al., 1989
1piv Poliovirus 3 Sabin (P3/Sabin; P3/Leon/12a(1)b) complexed with disoxaril (WIN 51711)  
1vba Poliovirus 3 Sabin (P3/Sabin; P3/Leon/12a(1)b) complexed with R78206 Grant et al., 1994
1vbb Poliovirus 3 Sabin (P3/Sabin; P3/Leon/12a(1)b) complexed with R80633 Grant et al., 1994
1vbc Poliovirus 3 Sabin (P3/Sabin; P3/Leon/12a(1)b) complexed with R77975 Grant et al., 1994
1vbe Poliovirus 3 Sabin (P3/Sabin; P3/Leon/12a(1)b) mutant 242-H2 complexed with R78206 Grant et al., 1994
CVA21 1z7s Coxsackievirus A21 Kuykendall C.Xiao, C.M.Bator-Kelly, E.Rieder, P.R.Chipman, A.Craig, R.J.Kuhn, E.Wimmer, M.G.Rossmann
CVA24 4Q4V CVA24v/110390/Malaysia/2002 [KF725085] Zocher et al., 2014
CVA24 4Q4W CVA24v/110390/Malaysia/2002 [KF725085] Zocher et al., 2014
CVA24 4Q4X CVA24v/110390/Malaysia/2002 [KF725085] Zocher et al., 2014
CVA24 4Q4Y CVA24v/110390/Malaysia/2002 [KF725085] Zocher et al., 2014
CVA9 1d4m Coxsackievirus A9 Griggs [D00627] Smyth et al., 1996; Hendry et al., 1999
CVB3 1cov Coxsackievirus B3 M Muckelbauer et al., 1995
CVB3 + CAR 1jew Cyro-EM structure of coxsackievirus B3 (M strain) with its cellular receptor, coxsackievirus and adenovirus receptor (CAR). He et al., 2001
CVB3 1rfr Structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf RNA Ohlenschlager et al., 2004
CVB4 1z8r coxsackievirus B4 (JVB Benschoten, New York, 1951) 2Apro Baxter et al., 2006
SVDV 1oop Swine vesicular disease virus (strain UKG/27/72) Fry et al., 2003
SVDV 1mqt Swine vesicular disease virus (strain SPA/2/93) Verdaguer et al., 2003
E-1 1ev1 Echovirus 1 Farouk [AF029859] Filman et al., 1998
E-7 1m11 Structural Model Of Human Decay-Accelerating Factor Bound To Echovirus 7 From Cryo-Electron Microscopy He et al., 2002
E-7 2x5i Crystal Structure Echovirus 7 Plevka et al., 2010
E-7 3iyp The Interaction Of Decay-Accelerating Factor With Echovirus 7 Plevka et al., 2010
E-11 1h8t Echovirus 11 Stuart et al., 2002
E-12 1upn Echovirus 12 Gregory with Domains 3 And 4 Of Its Receptor Decay Accelerating Factor (Cd55) By Cryo Electron Microscopy At 16 A Bhella et al., 2004
EV-A71 4aed Enterovirus A71 capsid Plevka et al., 2012
EV-E1 1bev Enterovirus E1 (BEV-1) VG(5)27 [D00214] Smyth et al., 1995
EV-F3 5mqu Enterovirus F3 (BEV-2) [X79368] Roedig et al., 2017
PV, poliovirus
CV-A, coxsackievirus A
CV-B, coxsackievirus B
E, echovirus
SVDV, swine vesicular disease virus
BEV, Bovine enterovirus


Basavappa, R., Syed, R., Flore, O., Icenogle, J.P., Filman, D.J. and Hogle, J.M. (1994). Role and mechanism of the maturation cleavage of VP0 in poliovirus assembly: structure of the empty capsid assembly intermediate at 2.9 A resolution. Protein Sci. 3: 1651-1669.

Baxter, N.J., Roetzer, A., Liebig, H.D., Sedelnikova, S.E., Hounslow, A.M., Skern, T. and Waltho, J.P. (2006). Structure and dynamics of coxsackievirus B4 2A proteinase, an enyzme involved in the etiology of heart disease. J. Virol. 80: 1451-1462.

Bhella, D., Goodfellow, I.G., Roversi, P., Pettigrew, D., Chaudhry, Y., Evans, D.J., Lea, S.M. (2004). The structure of echovirus type 12 bound to a two-domain fragment of its cellular attachment protein decay-accelerating factor (CD 55). J. Biol. Chem. 279: 8325-8332.

Filman, D.J., Syed, R., Chow, M., Macadam, A.J., Minor, P.D., Hogle, J.M. (1989). Structural factors that control conformational transitions and serotype specificity in type-3 poliovirus. EMBO J. 8: 1567-1579.

Filman, D.J., Wien, M.W., Cunningham, J.A., Bergelson, J.M. and Hogle, J.M. (1998). Structure determination of echovirus 1. Acta Crystallogr D Biol Crystallogr. 54: 1261-1272.

Fry, E.E., Knowles, N.J., Newman, J.W.I., Wilsden, G., Rao, Z., King, A.M.Q., and Stuart, D.I. (2003). Crystal structure of swine vesicular disease virus and implications for host adaptation. Journal of Virology 77: 5475-5486.

Grant, R.A., Hiremath, C.N., Filman, D.J., Syed, R., Andries, K. and Hogle, J.M. (1994). Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug design. Curr. Biol. 4: 784-797.

He, Y., Chipman, P.R., Howitt, J., Bator, C.M., Whitt, M.A., Baker, T.S., Kuhn, R.J., Anderson, C.W., Freimuth, P. and Rossmann, M.G. (2001). Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor. Nat. Struct. Biol. 8: 874-878.

He, Y., Lin, F., Chipman, P.R., Bator, C.M., Baker, T.S., Shoham, M., Kuhn, R.J., Medof, M.E. and Rossmann, M.G. (2002). Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex. Proc. Natl. Acad. Sci. USA 99: 10325-10329.

Hendry, E., Hatanaka, H., Fry, E., Smyth, M., Tate, J., Stanway, G., Santti, J., Maaronen, M., Hyypia, T. and Stuart, D.  (1999). The crystal structure of coxsackievirus A9: new insights into the uncoating mechanisms of enteroviruses. Structure Fold Des. 7: 1527-1538.

Hogle, J.M., Chow, M. and Filman, D.J. (1985). Three-dimensional structure of poliovirus at 2.9 A resolution. Science 229: 1358-1365.

Lentz, K.N., Smith, A.D., Geisler, S.C., Cox, S., Buontempo, P., Skelton, A., Martino, J., De Rozhon, E., Schwartz, J. and Girijavallabhan, V. (1997). Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of the three poliovirus serotypes. Structure 5: 961-978.

Muckelbauer, J.K., Kremer, M., Minor, I., Diana, G., Dutko, F.J., Groarke, J., Pevear, D.C. and Rossmann, M.G. (1995). The structure of coxsackievirus B3 at 3.5 Angstrom resolution. Structure 3: 653-667.

Ohlenschlager, O., Wohnert, J., Bucci, E., Seitz, S., Hafner, S., Ramachandran, R., Zell, R. and Gorlach, M. (2004). The structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf RNA and its interaction with the proteinase 3C. Structure (Camb) 12: 237-248.

Plevka, P., Perera, R., Cardosa, J., Kuhn, R.J. and Rossmann, M.G. (2012). Crystal structure of human enterovirus 71. Science 336(6086): 1274.

Roedig, P., Ginn, H.M., Pakendorf, T., Sutton, G., Harlos, K., Walter, T.S., Meyer, J., Fischer, P., Duman, R., Vartiainen, I., Reime, B., Warmer, M., Brewster, A.S., Young, I.D., Michels-Clark, T., Sauter, N.K., Kotecha, A., Kelly, J., Rowlands, D.J., Sikorsky, M., Nelson, S., Damiani, D.S., Alonso-Mori, R., Ren, J., Fry, E.E., David, C., Stuart, D.I., Wagner, A. and Meents, A. (2017). High-speed fixed-target serial virus crystallography. Nat. Methods 2017 Jun 19. doi: 10.1038/nmeth.4335. [Epub ahead of print]

Smyth, M., Tate, J., Hoey, E., Lyons, C., Martin, S. and Stuart, D. (1995). Implications for viral uncoating from the structure of bovine enterovirus. Structural Biology 2: 224-231.

Smyth, M., Tate, J., Stuart, D. and Hyypia, T. (1996). Crystal structure of coxsackievirus A9. Europic '96: IXth meeting of the European Study Group on the Molecular Biology of Picornaviruses, Gmunden, Austria, 18-24 May 1996: abstract C6.

Stuart, A.D., McKee, T.A., Williams, P.A., Harley, C., Shen, S., Stuart, D.I., Brown, T.D. and Lea, S,M. (2002). Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection. J. Virol. 76: 7694-7704.

Verdaguer, N., Jimenez-Clavero, M.A., Fita, I. and Ley, V. (2003). Structure of swine vesicular disease virus: mapping of changes occurring during adaptation of human coxsackie B5 virus to infect swine. J. Virol. 77: 9780-9789.

Yeates, T.O., Jacobson, D.H., Martin, A., Wychowski, C., Girard, M., Filman, D.J. and Hogle, J.M. (1991). Three-dimensional structure of a mouse-adapted type 2/type 1 poliovirus chimera. EMBO Journal 10: 2331-2341.

Zocher, G., Mistry, N., Frank, M., Hähnlein-Schick, I., Ekström, J.O., Arnberg, N. and Stehle, T. (2014). A Sialic acid binding site in a human picornavirus. PLoS Pathog. 2014 Oct 16;10(10):e1004401. doi: 10.1371/journal.ppat.1004401. eCollection 2014 Oct. PubMed PMID: 25329320.

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